Angela has a huge, melon-sized growth on the back of her neck that she fears will ruin her daughter's wedding and her daycare business. Loretta is terrified that her painful, oozing skin condition will get in the way of making her movie.

John is a sweet guy trying to get over his bumpy past, but not as bumpy as the huge growth on his shoulder. Tami has yellow deposits on her eyelids that make it impossible for her to feel beautiful.

Car lover Dave has 17 huge, painful head bumps that concern his girlfriend and make him feel like a freak. Melissa recently moved to a new town but her mysterious red, scaly lesions cover her legs and steal her confidence.

Jeana has huge, spherical growths dangling from her ears and the embarrassment is ruining her life. Alondra owns a flower shop but her painful, hydrangea-sized back bump prevents her from helping customers.

Tana deals with an abusive past, and a forehead bump has destroyed her food truck business aspirations. Vernestine, a die-hard Yankees fan, has a huge, misshapen growth on her back-- but her kidney disease may prevent her from getting it removed.

John is bound to a wheelchair and ready to give up after his legs have become too swollen, painful, and smelly to enjoy a fulfilling life. Chad's painful, giant hip growth has kept him from living his passion as an agile roller skater.

Veronica has a huge mango-sized growth on her back that has taken away her zest for life and desire for camping. Thomas has a deep passion for cosplay, but is too embarrassed to dress up due to the large, round bump on their head.

Candace is a charismatic singer and doula whose huge face bump is stealing her youth. Christian is a loving family man who has ignored the massive, terrifying growth hanging off his tush.

Dr. Tolson learns how to help Dr. Lee treat Mary Beth's bumpy, mysteriously-changing face lesions. An unexpected medical emergency sends Dr. Lee to the hospital.

Dr. Lee's occupational therapist arrives to help re-train her body post-stroke. Medical patient Justin arrives with a body-covering, angry rash that is creating a wedge between him and his girlfriend.

As Dr. Lee continues to recover from her stroke, she calls in reinforcements from Montana - her old dermatology residency pal, Dr. Kristen Townley. She assists Dr. Lee to help Cashanna, who is so ashamed of the clusters of bumps covering her eyelids.

As she continues to recover from her stroke, Dr. Lee again enlists her Montana friend Dr. Kristen Townley to remove Paul's concerning windpipe bump. The doctors also try to help Kellie, who has a large, possibly vascular lump on the side of her head.

Dr. Lee is cleared to perform surgery after her stroke. As she continues to rehab, she and Montana surgeon Dr. Kristen Townley work together to help Brandi, whose huge back bump is hurting her mobility - and her relationship with her new boyfriend.

Brittany's home and career life are in shambles since her nose and cheeks erupted with bright red, oozing bumps. Dr. Sheila Farhang joins Dr. Lee for a lesson on how to remove John's painful, inflamed cysts.

Dr. Lee is ready to take the lead on her first surgery since her stroke, with Dr. Townley now assisting. Quentin has a cantaloupe-sized bump on his tricep that is ruining his mechanic career and making his girlfriend miserable.

Craig fears the massive growth on his neck could prevent him from helping his sick mother. Gwen is covered in dry, itchy patches that are causing hair loss and devastating her confidence.

Singer, songwriter, and popaholic Sevyn Streeter visits Dr. Lee with her gorgeous friend Rose, who is concerned an unsightly shoulder lump is ruining her modeling career.

Charming Justin feels the thousands of bumps covering his face and body ruin his chance to find love. Reclusive Gene's girlfriend is frustrated that he will only leave the house to watch trains due to the gigantic lump on his head.

Tom's increasingly large, bulbous nose is obstructing his breathing and threatening his family's livelihood. Dr. Lyndsey meets her biggest challenge yet as she and Dr. Lee try to help hairstylist Kamaria with a painful neck bump.

Dr. Lee expresses appreciation to her friend Dr. Kristen Townley for supporting her post-stroke and in life. Matline has a passion for horseback riding, but a painful bump on her back could end her time in the saddle.