After the confrontation with Eddie at the end of season one, it’s now a few months later and Jackie is on the beach with her family. She’s cut ties with Eddie and is determined to dive back in and spend more time with her family.

After a morning dealing with Grace’s escalating anxiety, Jackie helps a struggling family speed along a test to diagnose a little boy’s cystic fibrosis. But cutting through the red tape leads to sending the patient home with the wrong information.

During an after-school playdate, Ginny and Kaitlin annoy Jackie with their presence, and Kaitlyn catches Jackie snorting a line of Adderal. Kevin tells Jackie he doesn't like Dr. O'Hara's offer of money for the girls, for fear of being indebted to her.

Jackie confronts Eddie about his stalking her and asks him to stay away from her family. Dr. Cooper and Jackie are at odds about how to treat a cancer patient’s nausea from chemo. Jackie provides the patient with medical marijuana, even though it’s illegal in New York. Zoey believes she's pregnant.

Jackie overreacts to Kevin’s movie date with Ginny Flynn and the girls. Mrs. Akalitus stations a security guard at the Pill-O-Matix, making access harder for Jackie. Mrs. Akalitus asks Dr. Cooper to be the “Face of All Saints,” a citywide ad campaign using his image to bring in more insured patients.

Jackie sleeps with Eddie at his apartment and tells him to stop seeing Kevin. Posters with Dr. Cooper's face are plastered all over the city, much to the disgust of Jackie and Dr. O'Hara.

Post-birthday party, Fiona busts her lip open on her cast, and Dr. O’Hara and Jackie stitch her up in the Peyton kitchen. Jackie notices Sarah Khouri’s philandering behavior and brings up her concerns to Dr. O’Hara.

Jackie deals with Fiona’s teacher’s concerns and suspicions about her busted lip and cast. Dr. Cooper sets his friend Georgia up with Eddie. Dr. O’Hara, having once again ended things with Sarah, takes comfort with spending time with Jackie and her family in Queens.

Jackie tells Kevin she wants to send Fiona to Immaculate with Grace. Kevin makes Jackie promise not to accept money from Dr. O’Hara. Jackie rents a P.O. Box in order to safely receive her secret credit card bill that she’s now using to pay for prescriptions.

Jackie shows Dr. O’Hara a fake MRI to get an oxy prescription. Dr. O’Hara confronts Orthopedics and finds out that Jackie faked her MRI. Mrs. Akalitus rehires Eddie as the hospital pharmacist.

After avoiding Eddie, O'Hara and the drug dealer who has come looking for his stolen pills, Jackie takes off early for a family vacation upstate. Kevin and the girls are excited, but every activity they've planned is a disaster.

After a disastrous family vacation, Jackie returns to work for a day of reckoning. The mounting pressures and conflicts in her personal and professional life reach a boiling point. Unexpected alliances lead to revelations that even Jackie can’t avoid.